Even though the theme is "Astronauts," I don't recall the boys ever actually playing that... But the closest thing was when they played the "Sci-Fi" theme in Phone Destroyer, which is set in space, so I went with that angle~
This has been the most time-consuming drawing of the week so far, a full 12 hours xD Oh, and Cartman's costume is the "A.W.E.S.O.M.-O" one, specifically the Fortnite collaboration version, since that fit his adult body best~ [Remember, for this week I'm drawing them as if they were 25 years old.]
